RESEARCH

Holzer RG, MacDougall CA, Atwood C, Courtright G, Green JE, and Jorcyk CL: Development and characterization of a progressive series of mammary      adenocarcinoma cell lines derived from the C3(1)/SV40 Large T-antigen transgenic mouse model.  Breast Cancer Res and Treatment  77: 65-76, 2003

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Holzer RG, Ryan RE, Tommack M, Schlekeway E and Jorcyk CL.  Oncostatin M stimulates the detachment of a reservoir of invasive mammary carcinoma cells: role of cyclooxygenase-2.  Clin Exp Metastasis  21: 167-76, 2004

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MacDougall CA, Vargas M, Soares CR, Holzer RG, Ide AE, Jorcyk, CL.  Involvement of HGF/SF-Met signaling in prostate adenocarcinoma cells: evidence for alternative mechanisms leading to a metastatic phenotype in Pr-14c.  Prostate  21: 167-76, 2004

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Queen MM, Ryan RE, Holzer RG, Keller-Peck CR, Jorcyk, CL.  Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression.  Cancer Res  65: 8896-904, 2005

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Jorcyk CL, Holzer RG, Ryan RE.  Oncostatin M induces cell detachment and enhances the metastatic capacity of T-47D human breast carcinoma cells.  Cytokine  33: 323-36, 2006

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Holzer RG, Ide AE, Ryan RE, Jorcyk CL:  Oncostatin-M-induced vascular endothelial growth factor (VEGF) expression stimulates angiogenesis in breast carcinoma in vitro and in vivo.  In preparation

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Gallagher E, Tenzler T, Matsuzawa A, Anzelon-Mills A, Otero D, Holzer R, Janssen E, Gao M, Karin M.  Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production.  Nat Immunology  8: 57-63, 2007

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Park EJ, Lee JH, Yu G-Y, He G, Ali SR, Holzer RG, Österreicher CO, Takahashi H, Karin M. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression.  Cell  140: 197-208, 2010

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Holzer RG, Park EJ, Tran H, Choi C, Li N, Solinas G, Karin M.  Saturated fatty acids activate JNK by inducing c-Src clustering within intracellular membrane subdomains.  Cell  147: 173-184, 2011.

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Li N, Wu X, Holzer RG, Lee J-H, Park E-J, Ogata H, Gukovskaya AS, Gukovsky I, Moscat J, Dia-Meco M, Deerinck T, Dawson D, VandenBerg S, Karin M.  Reduced IKK expression, defective completion of autophagy and accumulation of p62 aggregates result in spontaneous pancreatitis. Journal of Clinical Investigation.  In press, 2013.

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Holzer RG, Keats J, Garbitt V, Palmer S, Chesi M, Bergsagel PL. UTX regulates spontaneous
and bortezomib-induced apoptosis in multiple myeloma.  In preparation. 

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Holzer RG, Garbitt V, Palmer S, Chesi M, Bergsagel PL.  Role of obesity in the initiation and progression of multiple myeloma. In preparation.​

The Rosetta Institute of Biomedical Research is an independently funded medical research institute founded by Dr. Ryan Holzer, PhD. The institute is funded by internally generated revenue, and by private donations. Current research projects include elucidating the mechanisms of bortezomib (Velcade) resistance in multiple myeloma, the identification of ubiquitin ligases that regulate the survival of multiple myeloma cells and the identification of novel genes involved in the initiation and metastasis of soft tissue sarcomas. A variety of techniques are being used at the institute to address these questions, from bioinformatic analyses to tissue culture to zebrafish models of cancer.

PUBLICATIONS